DL-Serine hydroxamate

Name: DL-Serine hydroxamate
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CAS No. 55779-32-3
Cat. No. CS-0142371
Molecule weight120.11
Purity≥98%
MDL No.MFCD00055712

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Structure of 55779-32-3

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General Information

CAS No. 55779-32-3
Cat. No. CS-0142371
Purity ≥98%
MDL No. MFCD00055712
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃H₈N₂O₃
Molecular Weight 120.11
Synonym(s) None
SMILES O=C(NO)C(N)CO

Description

Inhibiting serine metabolism through competitive substrate mimicry, DL-Serine hydroxamate (CAS 55779-32-3) disrupts de novo biosynthesis pathways in mammalian cell lines and alters intracellular amino acid homeostasis.

Application

DL-Serine hydroxamate (CAS 55779-32-3) induces ppGpp synthesis in E. coli by mimicking amino acid starvation, triggering stringent response pathways. It halts tRNA charging. This disruption synchronizes bacterial cell cycles effectively.

Synthesis

Route1
- 2104-89-4
- ~%
- In-stock
  
  55779-32-3
References
- Botvinik,M.M. et al. J. Gen. Chem. USSR (Engl. Transl.), 1962 , vol. 32, p. 1382 - 1389,1369 - 1375

Safety Information

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Computational Chemistry Data

TPSA 95.58
LogP -2.1886
H_Acceptors 4
H_Donors 4
Rotatable_Bonds 2

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Serine and derivatives

Chemical Biology Peptide Chemistry Amino Acid Derivatives

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DL-Serine hydroxamate

CAS No. 55779-32-3

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