2-Chloro-N-(2-methoxyphenyl)acetamide

Name: 2-Chloro-N-(2-methoxyphenyl)acetamide
Brand: ChemScene
Availability: InStock
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CAS No. 55860-22-5
Cat. No. CS-0071878
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-N-(2-methoxyphenyl)acetamide|CS-0071878

Structure of 55860-22-5

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Description

2-Chloro-N-(2-methoxyphenyl)acetamide features a chlorinated acetyl group linked to a methoxy-substituted phenyl ring, delivering enhanced stability and tunable reactivity. This scaffold integrates electron-donating and halogen functionalities, enabling efficient coupling in synthetic transformations. The molecule exhibits favorable solubility in common organic solvents and maintains integrity under standard bench conditions.

Application

2-Chloro-N-(2-methoxyphenyl)acetamide serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted anilines and heterocyclic scaffolds. Its chloroacetamide functionality facilitates nucleophilic substitution and cyclization reactions under mild conditions, while the ortho-methoxyphenyl group provides steric and electronic modulation. The compound exhibits good bench stability and is readily purified by flash chromatography, making it well-suited for iterative synthesis workflows in API development.

General Information

CAS No. 55860-22-5
Cat. No. CS-0071878
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₀ClNO₂
Molecular Weight 199.63
Synonym(s) None
SMILES O=C(CCl)NC1=CC=CC=C1OC

Computational Chemistry Data

TPSA 38.33
LogP 1.8725
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 3

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 1759
Class : 8	Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501

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Other Classifications

Building Blocks Functional Group Amide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-Chloro-N-(2-methoxyphenyl)acetamide

CAS No. 55860-22-5

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