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CS-W001157 4
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2-Chloro-N-(2-methoxyphenyl)acetamide

  • CAS No. 55860-22-5

  • Cat. No. CS-0071878
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Chloro-N-(2-methoxyphenyl)acetamide|CS-0071878

Structure of 55860-22-5

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General Information

  • CAS No. 55860-22-5
  • Cat. No. CS-0071878
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀ClNO₂
  • Molecular Weight 199.63
  • Synonym(s) None
  • SMILES O=C(CCl)NC1=CC=CC=C1OC

Description

2-Chloro-N-(2-methoxyphenyl)acetamide features a chlorinated acetyl group linked to a methoxy-substituted phenyl ring, delivering enhanced stability and tunable reactivity. This scaffold integrates electron-donating and halogen functionalities, enabling efficient coupling in synthetic transformations. The molecule exhibits favorable solubility in common organic solvents and maintains integrity under standard bench conditions.

Application

2-Chloro-N-(2-methoxyphenyl)acetamide serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted anilines and heterocyclic scaffolds. Its chloroacetamide functionality facilitates nucleophilic substitution and cyclization reactions under mild conditions, while the ortho-methoxyphenyl group provides steric and electronic modulation. The compound exhibits good bench stability and is readily purified by flash chromatography, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • null|null
      90-04-0
    • null|null
      79-04-9
    • ~85%
    • In-stock
      2-Chloro-N-(2-methoxyphenyl)acetamide|CS-0071878
      55860-22-5

    References

    • Farmaco, , vol. 57, # 3 p. 201 - 206
  • Route2
    • null|null
      90-04-0
    • ~81%
    • In-stock
      2-Chloro-N-(2-methoxyphenyl)acetamide|CS-0071878
      55860-22-5

    References

    • US2004/29887 A1, ;
  • Route3

    References

    • Tetrahedron Letters, , vol. 40, # 49 p. 8563 - 8566

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   1.8725
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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