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Structure of 56108-12-4
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4-tert-Butylbenzamide features a sterically hindered tert-butyl group that enhances stability and modulates solubility. This aromatic amide integrates readily into synthetic scaffolds requiring electron-donating, bulky substituents. The para-substitution pattern ensures predictable reactivity in coupling processes and facilitates purification through crystallization.
4-tert-Butylbenzamide serves as a versatile building block in medicinal chemistry, offering a robust aromatic amide scaffold with enhanced lipophilicity and metabolic stability. Its tert-butyl group provides steric bulk and improved solubility characteristics, while the amide functionality enables reliable coupling reactions and hydrogen bonding interactions. The compound exhibits excellent bench stability and compatibility with standard synthetic transformations, facilitating efficient incorporation into diverse heterocyclic systems and API candidates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H319
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Precautionary Statements : P264-P270-P280-P301+P310-P305+P351+P338-P330-P337+P313-P501
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Lot numbers can be found on the outside label of a product: