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Structure of 57381-34-7
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5-Chloro-2-fluorobenzonitrile is a fluorinated aromatic nitrile featuring complementary halogen substituents at the 5- and 2-positions. This electron-deficient aryl building block enables direct coupling in transition-metal-catalyzed reactions, offering enhanced reactivity and selectivity in pharmaceutical and agrochemical synthesis.
5-Chloro-2-fluorobenzonitrile serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds via nucleophilic aromatic substitution. Its ortho-fluoro and meta-chloro substituents provide complementary reactivity for selective functionalization, while the nitrile group offers high stability and compatibility with diverse reaction conditions. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for scale-up applications in multi-step syntheses.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: