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Ethyl 2-(thiophen-2-yl)acetate

  • CAS No. 57382-97-5

  • Cat. No. CS-0042492
  • Purity≥97%
  • MDL No.MFCD00005457

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-(thiophen-2-yl)acetate|CS-0042492

Structure of 57382-97-5

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General Information

  • CAS No. 57382-97-5
  • Cat. No. CS-0042492
  • Purity ≥97%
  • MDL No. MFCD00005457
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀O₂S
  • Molecular Weight 170.23
  • Synonym(s) Thiophene-2-aceticacidethylester
  • SMILES O=C(OCC)CC1=CC=CS1

Description

Ethyl 2-(thiophen-2-yl)acetate features a thiophene ring directly linked to an acetic acid ester moiety, delivering a robust scaffold for heterocyclic synthesis. This bench-stable compound integrates readily into transition-metal-catalyzed couplings and serves as a key building block in pharmaceutical and agrochemical research.

Application

Ethyl 2-(thiophen-2-yl)acetate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to thiophene-fused scaffolds via Pd-catalyzed cross-coupling and Michael addition reactions. The ester functionality provides synthetic handle for further derivatization, while the thiophene ring imparts stability and π-conjugation beneficial for pharmaceutical and materials applications. Its bench-stable nature and compatibility with standard reaction conditions facilitate straightforward purification and scalability in industrial R&D workflows.

Synthesis

  • Route1
    • 2-Thiopheneacetic acid Cefoxitin  Impurity|CS-0229338
      1918-77-0
    • null|null
      64-17-5
    • ~95%
    • In-stock
      Ethyl 2-(thiophen-2-yl)acetate|CS-0042492
      57382-97-5

    References

    • Revotar Biopharmaceuticals AG Patent: EP1764093 A1, 2007 ; Location in patent: Page/Page column 19-20 ;
  • Route2
    • null|null
      1003-09-4
    • In-stock
      3-Ethoxy-3-oxopropanoic acid potassium|CS-D1444
      6148-64-7
    • ~92%
    • In-stock
      Ethyl 2-(thiophen-2-yl)acetate|CS-0042492
      57382-97-5

    References

    • Feng, Yi-Si; Wu, Wei; Xu, Zhong-Qiu; Li, Yan; Li, Ming; Xu, Hua-Jian Tetrahedron, 2012 , vol. 68, # 9 p. 2113 - 2120
  • Route3
    • null|null
      6165-68-0
    • null|null
      105-36-2
    • ~33%
    • In-stock
      Ethyl 2-(thiophen-2-yl)acetate|CS-0042492
      57382-97-5

    References

    • Goossen Chemical Communications, 2001 , # 7 p. 669 - 670

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.8537
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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