2-Bromo-1-(5-chlorothiophen-2-yl)ethanone

Name: 2-Bromo-1-(5-chlorothiophen-2-yl)ethanone
Brand: ChemScene
Availability: InStock
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CAS No. 57731-17-6
Cat. No. CS-0060157
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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2-Bromo-1-(5-chlorothiophen-2-yl)ethanone|CS-0060157

Structure of 57731-17-6

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General Information

CAS No. 57731-17-6
Cat. No. CS-0060157
Purity ≥95%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄BrClOS
Molecular Weight 239.52
Synonym(s) 2-BROMO-1-(5-CHLORO-THIOPHEN-2-YL)-ETHANONE
SMILES C1=C(C(=O)CBr)SC(=C1)Cl

Description

2-Bromo-1-(5-chlorothiophen-2-yl)ethanone features a brominated ketone moiety fused to a chlorothiophene ring, delivering high reactivity in cross-coupling and heterocyclic synthesis. This bench-stable compound integrates readily into complex molecular architectures under standard conditions.

Application

2-Bromo-1-(5-chlorothiophen-2-yl)ethanone serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of heterocyclic scaffolds and functionalized alkylated derivatives. Its bromo group facilitates palladium-catalyzed cross-coupling reactions, while the chlorothiophene moiety provides orthogonal reactivity for downstream modifications. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for medicinal chemistry and process development workflows.

Synthesis

Route1
- 6310-09-4
- ~77%
- In-stock
  
  57731-17-6
References
- Salonen, Laura M.; Holland, Mareike C.; Kaib, Philip S. J.; Haap, Wolfgang; Benz, Joerg; Mary, Jean-Luc; Kuster, Olivier; Schweizer, W. Bernd; Banner, David W.; Diederich, Francois Chemistry - A European Journal, 2012 , vol. 18, # 1 p. 213 - 222

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 1759
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 17.07
LogP 2.9791
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Ketone

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Thiophene compounds

Key Words

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2-Bromo-1-(5-chlorothiophen-2-yl)ethanone

CAS No. 57731-17-6

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