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Structure of 58083-59-3
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6-Chloroisoindolin-1-one is a bench-stable, electron-deficient heterocycle featuring a chlorinated isoindolinone core. This scaffold integrates readily into synthetic sequences requiring moderate electrophilicity and enhanced solubility in polar aprotic solvents. The para-chloro substitution enables downstream functionalization via palladium-catalyzed cross-coupling or nucleophilic displacement, streamlining access to complex pharmaceutical intermediates and bioactive compounds.
6-Chloroisoindolin-1-one serves as a versatile building block in medicinal chemistry, enabling efficient construction of substituted isoindolinone scaffolds. Its chlorine substituent facilitates nucleophilic aromatic substitution and palladium-catalyzed coupling reactions, offering predictable reactivity for late-stage functionalization. The compound exhibits good bench stability and is readily purified by flash chromatography, making it well-suited for high-throughput synthesis and API development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: