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CS-W001157 4
Total: USD 88.00

tert-Butyl 4-(mercaptomethyl)piperidine-1-carboxylate

  • CAS No. 581060-27-7

  • Cat. No. CS-0079696
  • Purity≥95%
  • MDL No.MFCD19689418
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(mercaptomethyl)piperidine-1-carboxylate|CS-0079696

Structure of 581060-27-7

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Description

tert-Butyl 4-(mercaptomethyl)piperidine-1-carboxylate features a piperidine core bearing a thiol-functionalized alkyl side chain, enabling direct conjugation via gold or copper-mediated coupling. The tert-butyl ester group provides stability and convenient deprotection under mild acidic conditions. This compound serves as a key building block for cysteine-targeted bioconjugations and peptide modifications in chemical biology workflows.

Application

tert-Butyl 4-(mercaptomethyl)piperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling the installation of a piperidine-linked thioether motif. The protected thiol functionality exhibits good bench stability and undergoes selective oxidation or cross-coupling reactions, facilitating access to sulfide-containing heterocycles and bioactive scaffolds. Its compatibility with standard synthetic protocols makes it ideal for modular library synthesis.

General Information

  • CAS No. 581060-27-7
  • Cat. No. CS-0079696
  • Purity ≥95%
  • MDL No. MFCD19689418
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₁NO₂S
  • Molecular Weight 231.35
  • Synonym(s) 1-Boc-4-(Mercaptomethyl)piperidine
  • SMILES O=C(OC(C)(C)C)N1CCC(CS)CC1

Computational Chemistry Data

  • TPSA   29.54
  • LogP   2.5633
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS08,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group :
Hazard Statements : H315-H319-H372-H413
Precautionary Statements : P264-P273-P280-P302+P352-P362-P501

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