4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine

Name: 4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 582313-57-3
Cat. No. CS-0054793
Purity≥96%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine|CS-0054793

Structure of 582313-57-3

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Description

4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine is a heterocyclic building block featuring orthogonal halogen handles for selective functionalization. This electron-deficient scaffold enables efficient coupling in cross-coupling reactions and serves as a key intermediate in the synthesis of kinase inhibitors and nucleoside analogs.

Application

4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of purine-based scaffolds. Its orthogonal halogenation pattern facilitates palladium-catalyzed cross-coupling reactions and nucleophilic substitution, offering high functional group tolerance and bench stability. This compound functions as a key intermediate in the synthesis of kinase inhibitors and antiviral agents, with predictable reactivity under standard conditions.

General Information

CAS No. 582313-57-3
Cat. No. CS-0054793
Purity ≥96%
MDL No. None
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃ClFN₃
Molecular Weight 171.56
Synonym(s) 7H-Pyrrolo[2,3-d]pyrimidine,4-chloro-5-fluoro-
SMILES FC1=CNC2=C1C(Cl)=NC=N2

Computational Chemistry Data

TPSA 41.57
LogP 1.7504
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrrole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine

CAS No. 582313-57-3

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