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Structure of 582325-22-2
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6-(3-Fluorophenyl)nicotinic acid features a fluorinated phenyl ring directly attached to the nicotinic acid scaffold, enhancing electron-withdrawal and metabolic stability. This substitution pattern imparts favorable pharmacokinetic properties and enables direct incorporation into bioactive heterocycles for medicinal chemistry applications.
6-(3-Fluorophenyl)nicotinic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its structure combines a pyridine core with an electron-deficient 3-fluorophenyl substituent, enabling efficient coupling reactions via Suzuki, Stille, or direct arylation. The carboxylic acid functionality facilitates derivatization into amides, esters, or acyl chlorides, supporting downstream functionalization in medicinal chemistry campaigns. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H312-H332
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
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Lot numbers can be found on the outside label of a product: