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CS-W001157 4
Total: USD 88.00

6-(3-Fluorophenyl)nicotinic acid

  • CAS No. 582325-22-2

  • Cat. No. CS-0156904
  • Purity≥98%
  • MDL No.MFCD06410387
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6-(3-Fluorophenyl)nicotinic acid|CS-0156904

Structure of 582325-22-2

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Description

6-(3-Fluorophenyl)nicotinic acid features a fluorinated phenyl ring directly attached to the nicotinic acid scaffold, enhancing electron-withdrawal and metabolic stability. This substitution pattern imparts favorable pharmacokinetic properties and enables direct incorporation into bioactive heterocycles for medicinal chemistry applications.

Application

6-(3-Fluorophenyl)nicotinic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its structure combines a pyridine core with an electron-deficient 3-fluorophenyl substituent, enabling efficient coupling reactions via Suzuki, Stille, or direct arylation. The carboxylic acid functionality facilitates derivatization into amides, esters, or acyl chlorides, supporting downstream functionalization in medicinal chemistry campaigns. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows.

General Information

  • CAS No. 582325-22-2
  • Cat. No. CS-0156904
  • Purity ≥98%
  • MDL No. MFCD06410387
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₈FNO₂
  • Molecular Weight 217.20
  • Synonym(s) 6-(3-Fluorophenyl)-nicotinic acid
  • SMILES C1=CC(=CC(=C1)F)C2=NC=C(C=C2)C(=O)O

Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.5859
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

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