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CS-W001157 4
Total: USD 88.00

2-Hydroxy-4-(methylthio)butyric acid

  • CAS No. 583-91-5

  • Cat. No. CS-0066284
  • Purity≥88%
  • MDL No.MFCD00070490

*For research and further manufacturing use only, not for direct human use.

2-Hydroxy-4-(methylthio)butyric acid|CS-0066284

Structure of 583-91-5

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General Information

  • CAS No. 583-91-5
  • Cat. No. CS-0066284
  • Purity ≥88%
  • MDL No. MFCD00070490
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₀O₃S
  • Molecular Weight 150.20
  • Synonym(s) None
  • SMILES O=C(C(CCSC)O)O

Description

2-Hydroxy-4-(methylthio)butyric acid features a reactive hydroxyl group and a sulfide-containing side chain, enabling selective derivatization in synthetic peptide and small-molecule workflows. This bench-stable, moisture-tolerant reagent integrates readily into polar reaction environments, offering enhanced solubility and functional group compatibility for advanced conjugation strategies.

Application

2-Hydroxy-4-(methylthio)butyric acid serves as a versatile building block in synthetic organic chemistry, enabling the construction of bioactive heterocycles and peptide mimetics. Its hydroxyl and thioether functionalities offer orthogonal reactivity for selective derivatization, while the carboxylic acid facilitates coupling reactions under standard conditions. The molecule exhibits bench stability and compatibility with common protecting group strategies, making it well-suited for iterative synthesis workflows in medicinal chemistry and process development.

Synthesis

  • Route1
    • null|null
      1003880-00-9
    • ~46%
    • In-stock
      2-Hydroxy-4-(methylthio)butyric acid|CS-0066284
      583-91-5

    References

    • SUMITOMO CHEMICAL COMPANY, LIMITED Patent: WO2008/10609 A1, 2008 ; Location in patent: Page/Page column 32-33 ;
  • Route2

    References

    • WO2012/81712 A1, ; Page/Page column 20 ;
  • Route3
    • In-stock
      3-Hydroxydihydrofuran-2(3H)-one|CS-W013699
      19444-84-9
    • null|null
      5188-07-8
    • ~99%
    • In-stock
      2-Hydroxy-4-(methylthio)butyric acid|CS-0066284
      583-91-5

    References

    • Deck, Patrick; Exner, Kai Michael; Buschhaus, Boris Patent: US2009/318715 A1, 2009 ; Location in patent: Page/Page column 4 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅱ
Hazard Statements : H315-H318-H412
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   0.185
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   4

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