2-(2,4-Difluorophenyl)-5-methylpyridine

Name: 2-(2,4-Difluorophenyl)-5-methylpyridine
Brand: ChemScene
Availability: InStock
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CAS No. 583052-21-5
Cat. No. CS-0062054
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-(2,4-Difluorophenyl)-5-methylpyridine|CS-0062054

Structure of 583052-21-5

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Description

This pyridine derivative features a 2,4-difluorophenyl group conjugated to a methyl-substituted pyridine core, delivering enhanced electron density and metabolic stability. It serves as a key scaffold in medicinal chemistry for kinase inhibitors and CNS-targeted therapeutics, offering favorable solubility and synthetic handle accessibility under standard conditions.

Application

2-(2,4-Difluorophenyl)-5-methylpyridine serves as a valuable building block in medicinal chemistry, enabling the construction of biologically active heterocyclic scaffolds. Its structural motif combines a fluorinated aromatic ring with a substituted pyridine core, offering enhanced metabolic stability and favorable pharmacokinetic properties. The compound exhibits good bench stability and facilitates diverse coupling reactions, making it well-suited for parallel synthesis campaigns targeting kinase inhibitors and CNS-active agents.

General Information

CAS No. 583052-21-5
Cat. No. CS-0062054
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₉F₂N
Molecular Weight 205.20
Synonym(s) None
SMILES FC1=CC(F)=CC=C1C2=CC=C(C)C=N2

Computational Chemistry Data

TPSA 12.89
LogP 3.33522
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Key Words

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2-(2,4-Difluorophenyl)-5-methylpyridine

CAS No. 583052-21-5

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