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CS-W001157 4
Total: USD 88.00

2-Iodopyridine-4-carboxylic acid

  • CAS No. 58481-10-0

  • Cat. No. CS-W003990
  • Purity≥96%
  • MDL No.MFCD06800803

*For research and further manufacturing use only, not for direct human use.

2-Iodopyridine-4-carboxylic acid|CS-W003990

Structure of 58481-10-0

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General Information

  • CAS No. 58481-10-0
  • Cat. No. CS-W003990
  • Purity ≥96%
  • MDL No. MFCD06800803
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄INO₂
  • Molecular Weight 249.01
  • Synonym(s) 2-IODO-ISONICOTINIC ACID
  • SMILES Ic1nccc(c1)C(=O)O

Description

2-Iodopyridine-4-carboxylic acid features a strategically positioned iodine atom and carboxylic acid group on the pyridine ring, enabling direct functionalization in cross-coupling reactions. This dual-functional scaffold integrates readily into bioactive molecules and serves as a key building block in medicinal chemistry and materials science.

Application

2-Iodopyridine-4-carboxylic acid serves as a versatile building block for C–H functionalization and cross-coupling reactions, enabling efficient access to substituted pyridine scaffolds. The iodide group facilitates palladium-catalyzed coupling with arylboranes, alkenes, and heteroatom nucleophiles, while the carboxylic acid functions as a handle for derivatization or metal complexation. Its bench-stable crystalline form supports straightforward handling and purification in synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.3844
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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