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CS-W001157 4
Total: USD 88.00

6,7-Dihydro-8(5H)-quinolinone oxime

  • CAS No. 58509-59-4

  • Cat. No. CS-M0359
  • Purity≥95%
  • MDL No.MFCD20921531

*For research and further manufacturing use only, not for direct human use.

6,7-Dihydro-8(5H)-quinolinone oxime|CS-M0359

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General Information

  • CAS No. 58509-59-4
  • Cat. No. CS-M0359
  • Purity ≥95%
  • MDL No. MFCD20921531
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀N₂O
  • Molecular Weight 162.19
  • Synonym(s) (E)-6,7-dihydroquinolin-8(5H)-one oxime
  • SMILES O/N=C1C2=NC=CC=C2CCC/1

Description

6,7-Dihydro-8(5H)-quinolinone oxime features a fused heterocyclic core with a strategically positioned oxime functional group, enabling direct participation in nucleophilic transformations and cycloaddition reactions. This scaffold offers enhanced stability under standard bench conditions while maintaining high reactivity for downstream derivatization.

Application

6,7-Dihydro-8(5H)-quinolinone oxime serves as a versatile intermediate in heterocyclic synthesis, enabling efficient access to quinoline-based scaffolds through standard oxime transformations. Its stability under routine reaction conditions and compatibility with diverse functional groups facilitate reliable derivatization for medicinal chemistry applications.

Synthesis

  • Route1

    References

    • Wang, Deping; Zhang, Fuxing; Kuang, Daizhi; Yu, Jiangxi; Li, Junhua Green Chemistry, 2012 , vol. 14, # 5 p. 1268 - 1271
  • Route2

    References

    • Crawford, Jason B.; Chen, Gang; Gauthier, David; Wilson, Trevor; Carpenter, Bryon; Baird, Ian R.; McEachern, Ernie; Kaller, Alan; Harwig, Curtis; Atsma, Bem; Skerlj, Renato T.; Bridger, Gary J. Organic Process Research and Development, 2008 , vol. 12, # 5 p. 823 - 830

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1325
Class : 4.1
Packing Group : Ⅲ
Hazard Statements : H228-H302-H315-H319-H335
Precautionary Statements : P210-P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   45.48
  • LogP   1.5962
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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