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(2s)-3-(Dimethylamino)-2-({[(9h-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid

  • CAS No. 587880-86-2

  • Cat. No. CS-0246718
  • Molecule weight354.40
  • Purity≥95%
  • MDL No.MFCD02682424

*For research and further manufacturing use only, not for direct human use.

(2s)-3-(Dimethylamino)-2-({[(9h-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid|CS-0246718

Structure of 587880-86-2

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General Information

  • CAS No. 587880-86-2
  • Cat. No. CS-0246718
  • Purity ≥95%
  • MDL No. MFCD02682424
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₂₂N₂O₄
  • Molecular Weight 354.40
  • Synonym(s) Fmoc-l-2-amino-3-(dimethylamino)-propionic acid
  • SMILES O=C(O)[C@@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)CN(C)C

Description

This fluoren-9-ylmethoxycarbonyl-protected amino acid derivative features a chiral (2S) configuration and a dimethylamino group at the C3 position, enabling efficient incorporation into peptide chains. The robust fluorenylmethoxycarbonyl (Fmoc) moiety ensures stable protection during solid-phase synthesis, while the electron-rich aromatic system enhances solubility and compatibility with standard coupling protocols.

Application

(2S)-3-(Dimethylamino)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid serves as a key chiral building block in peptide synthesis, offering high stability and compatibility with standard coupling protocols. The Fmoc-protected amine enables efficient sequential elongation, while the dimethylamino group provides enhanced solubility and facilitates purification. Its well-defined stereochemistry ensures reliable incorporation into complex peptides and peptidomimetics.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   78.87
  • LogP   2.5399
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   6

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