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CS-W001157 4
Total: USD 88.00

3,5-Dichlorophenol

  • CAS No. 591-35-5

  • Cat. No. CS-W004113
  • Purity≥98%
  • MDL No.MFCD00002259

*For research and further manufacturing use only, not for direct human use.

3,5-Dichlorophenol|CS-W004113

Structure of 591-35-5

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General Information

  • CAS No. 591-35-5
  • Cat. No. CS-W004113
  • Purity ≥98%
  • MDL No. MFCD00002259
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄Cl₂O
  • Molecular Weight 163.00
  • Synonym(s) Phenol, 3,5-dichloro-; 3,5-Dichlorophenol
  • SMILES Oc1cc(Cl)cc(c1)Cl

Description

3,5-Dichlorophenol features a phenolic hydroxyl group flanked by two chlorine substituents at the meta positions, conferring enhanced electron-withdrawing character and improved stability under standard conditions. This configuration facilitates direct electrophilic substitution and serves as a robust scaffold for synthesizing agrochemical intermediates, pharmaceuticals, and functionalized polymers.

Application

3,5-Dichlorophenol serves as a valuable building block in medicinal chemistry and agrochemical synthesis, offering predictable reactivity at the phenolic hydroxyl group. Its ortho-chlorine substitution pattern enhances stability and facilitates electrophilic aromatic substitution or nucleophilic displacement reactions. The molecule exhibits good bench stability and ease of purification, enabling reliable use in coupling reactions, ether formation, and heterocycle construction under standard laboratory conditions.

Synthesis

  • Route1
    • null|null
      1338215-37-4
    • ~86%
    • In-stock
      3,5-Dichlorophenol|CS-W004113
      591-35-5

    References

    • Dibakar, Mullick; Prakash, Anjanappa; Selvakumar, Kumaravel; Ruckmani, Kandasamy; Sivakumar, Manickam Tetrahedron Letters, 2011 , vol. 52, # 41 p. 5338 - 5341
  • Route2
    • null|null
      93915-85-6
    • ~91%
    • In-stock
      3,5-Dichlorophenol|CS-W004113
      591-35-5

    References

    • Sala, Roberto; Doria, Gianfederico; Passarotti, Carlo Tetrahedron Letters, 1984 , vol. 25, # 40 p. 4565 - 4568
  • Route3

    References

    • US2004/30197 A1, ; Page 19-21 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06,GHS09
Signal Word : Danger
UN#: 2020
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H311-H314-H411
Precautionary Statements : P260-P264-P270-P273-P280-P301+P330+P331-P302+P352-P304+P340-P330-P361+P364-P363-P391-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.699
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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