Lot numbers can be found on the outside label of a product:
Ethyl 4-(hydroxymethyl)picolinate
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CAS No. 59663-96-6
- Cat. No. CS-0151671
- Purity≥97%
- MDL No.MFCD09844039
*For research and further manufacturing use only, not for direct human use.
Structure of 59663-96-6
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General Information
- CAS No. 59663-96-6
- Cat. No. CS-0151671
- Purity ≥97%
- MDL No. MFCD09844039
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₁₁NO₃
- Molecular Weight 181.19
- Synonym(s) ethyl 4-(hydroxyMethyl)picolite
- SMILES CCOC(=O)C1=NC=CC(=C1)CO
Description
Ethyl 4-(hydroxymethyl)picolinate features a hydroxymethyl group at the 4-position of the picolinate ring, enabling direct functionalization in synthetic transformations. This bench-stable ester integrates readily into medicinal chemistry workflows, offering a handle for derivatization while maintaining solubility and compatibility with common reaction conditions.
Application
Ethyl 4-(hydroxymethyl)picolinate serves as a versatile building block in medicinal chemistry, enabling straightforward derivatization of the pyridine core. The hydroxymethyl group facilitates oxidation to the carboxylic acid, reductive alkylation, or ether formation, while the ester functionality supports selective transformations. Its bench-stable nature and compatibility with standard coupling and protection protocols make it well-suited for iterative synthesis workflows targeting heterocyclic scaffolds and API intermediates.
Synthesis
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Route1
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64-17-5 -
In-stock
71935-32-5 - ~15%
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In-stock
59663-96-6
References
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SANTEN PHARMACEUTICAL CO., LTD. Patent: EP1602647 A1, 2005 ; Location in patent: Page/Page column 53 ;
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Route2
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In-stock
586-95-8 - ~%
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In-stock
59663-96-6
References
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El Hadri; Leclerc Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 3 p. 631 - 635
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Route3
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117423-41-3 - ~%
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In-stock
59663-96-6
References
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El Hadri; Leclerc Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 3 p. 631 - 635
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 59.42
- LogP 0.7506
- H_Acceptors 4
- H_Donors 1
- Rotatable_Bonds 3
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