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Structure of 60061-68-9
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4-Bromo-3-methyl-5-(trifluoromethyl)-1H-pyrazole is a fluorinated heterocyclic building block featuring a bromine atom at the 4-position and a trifluoromethyl group at the 5-position. This electron-deficient pyrazole scaffold enables efficient cross-coupling reactions, offering high stability under standard conditions. The methyl substituent enhances regioselectivity in synthetic transformations.
4-Bromo-3-methyl-5-(trifluoromethyl)-1H-pyrazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo functionality. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the methyl substituent provides steric control. This compound functions effectively in Suzuki-Miyaura, Stille, and Negishi couplings, offering reliable access to substituted pyrazole scaffolds commonly found in bioactive molecules. Its bench-stable nature and ease of purification support scalable synthesis.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: