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Structure of 601-99-0
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2-Hydroxy-6-nitrobenzoic acid features a strategically positioned nitro group and hydroxyl moiety on adjacent carbons of the aromatic ring, enhancing its reactivity in electrophilic substitution and enabling efficient coupling reactions. This ortho-functionalized scaffold serves as a key intermediate in the synthesis of fluorescent probes and bioactive heterocycles under standard conditions.
2-Hydroxy-6-nitrobenzoic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to substituted quinoline and benzoxazole scaffolds. Its ortho-hydroxyl and nitro groups facilitate directed metalation and electrophilic substitution, while the carboxylic acid supports derivatization via amide or ester formation. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: