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Structure of 60154-05-4
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5-Iodo-1-methylpyridin-2(1H)-one features a pyridinone core with a strategically positioned iodine at the 5-position and a methyl group at nitrogen, enabling direct functionalization in cross-coupling reactions. This bench-stable heterocycle integrates readily into complex molecular architectures, particularly in medicinal chemistry and materials science applications where halogenation facilitates downstream derivatization.
5-Iodo-1-methylpyridin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable iodo substituent and orthogonal reactivity of the pyridinone core. The 1-methyl group enhances solubility and metabolic stability, while the lactam functionality provides hydrogen-bonding capacity for target binding. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for modular synthesis of bioactive heterocycles and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: