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CS-W001157 4
Total: USD 88.00

KAT8-IN-1

  • CAS No. 605-62-9

  • Cat. No. CS-W015955
  • Molecule weight189.17
  • Purity≥98%
  • MDL No.MFCD02179392

*For research and further manufacturing use only, not for direct human use.

KAT8-IN-1|CS-W015955

Structure of 605-62-9

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General Information

  • CAS No. 605-62-9
  • Cat. No. CS-W015955
  • Purity ≥98%
  • MDL No. MFCD02179392
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇NO₃
  • Molecular Weight 189.17
  • Synonym(s) 4-Nitro-1-naphthol;4-Nitronaphthalen-1-OL
  • SMILES OC1=C2C=CC=CC2=C([N+]([O-])=O)C=C1

Description

KAT8-IN-1 is a potent, selective inhibitor of the KAT8 histone acetyltransferase enzyme. This small molecule modulates epigenetic signaling by targeting the catalytic domain of KAT8, disrupting its ability to acetylate lysine residues on histone H3. Designed for use in biochemical and cellular assays, it enables precise interrogation of KAT8-dependent transcriptional regulation. Its high specificity supports clean phenotypic readouts in epigenetic research.

Synthesis

  • Route1
    • null|null
      86-57-7
    • ~88%
    • In-stock
      KAT8-IN-1|CS-W015955
      605-62-9

    References

    • Makosza, Mieczyslaw; Sienkiewicz, Krzysztof Journal of Organic Chemistry, 1990 , vol. 55, # 17 p. 4979 - 4981
  • Route2
    • null|null
      86-57-7
    • ~86%
    • In-stock
      KAT8-IN-1|CS-W015955
      605-62-9
    • In-stock
      1-Nitronaphthalen-2-ol|CS-0146754
      550-60-7

    References

    • Makosza, Mieczyslaw; Sienkiewicz, Krzysztof Journal of Organic Chemistry, 1998 , vol. 63, # 13 p. 4199 - 4208
  • Route3
    • 1-Naphthol Duloxetine Impurity|CS-0213938
      90-15-3
    • ~75%
    • In-stock
      KAT8-IN-1|CS-W015955
      605-62-9

    References

    • Kalbasi, Roozbeh Javad; Massah, Ahmad Reza; Zamani, Farzad; Hamid, Javaherian Naghash Chinese Journal of Chemistry, 2010 , vol. 28, # 3 p. 397 - 403

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364

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Computational Chemistry Data

  • TPSA   63.37
  • LogP   2.4536
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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