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Structure of 606-27-9
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Methyl 2-nitrobenzoate features a para-nitro group flanking a methyl ester on a benzene ring, delivering enhanced electron-withdrawing character. This configuration enables efficient participation in nucleophilic aromatic substitution and facilitates coupling reactions under mild conditions. The compound exhibits bench-stable handling properties and integrates readily into synthetic sequences requiring controlled reactivity.
Methyl 2-nitrobenzoate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted benzimidazoles and other heterocyclic scaffolds via cyclization protocols. Its ortho-nitro group facilitates directed metalation and subsequent functionalization, while the ester moiety offers compatibility with standard reduction, coupling, and nucleophilic substitution reactions. The compound exhibits excellent bench stability and is readily purified by recrystallization or flash chromatography, making it well-suited for iterative synthesis workflows in medicinal chemistry and process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: