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CS-W001157 4
Total: USD 88.00

4-Methoxyquinoline

  • CAS No. 607-31-8

  • Cat. No. CS-0172913
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Methoxyquinoline|CS-0172913

Structure of 607-31-8

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General Information

  • CAS No. 607-31-8
  • Cat. No. CS-0172913
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉NO
  • Molecular Weight 159.18
  • Synonym(s) quinoline, 4-methoxy-
  • SMILES N=1C=CC(OC)=C2C=CC=CC12

Description

4-Methoxyquinoline is a heterocyclic compound featuring a quinoline core with a methoxy group at the 4-position, conferring enhanced solubility and electron-donating character. This configuration supports its use in medicinal chemistry and as a ligand in transition metal catalysis. The molecule exhibits stability under standard bench conditions and integrates readily into complex molecular architectures.

Application

4-Methoxyquinoline serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to quinoline-based scaffolds through standard electrophilic substitution and transition-metal-catalyzed coupling reactions. Its methoxy group enhances solubility and modulates electronic properties, while the core structure exhibits robust bench stability and compatibility with diverse functional groups, facilitating downstream derivatization in API synthesis.

Synthesis

  • Route1
    • In-stock
      4-Chloroquinoline|CS-W007603
      611-35-8
    • null|null
      124-41-4
    • ~87%
    • In-stock
      4-Methoxyquinoline|CS-0172913
      607-31-8

    References

    • Nasiri, Hamid Reza; Bolte, Michael; Schwalbe, Harald Heterocyclic Communications, 2006 , vol. 12, # 5 p. 319 - 322
  • Route2
    • 7-Chloro-4-methoxyquinoline|CS-0530875
      26707-52-8
    • ~97%
    • In-stock
      4-Methoxyquinoline|CS-0172913
      607-31-8

    References

    • Larionov, Oleg V.; Stephens, David; Mfuh, Adelphe; Chavez, Gabriel Organic Letters, 2014 , vol. 16, # 3 p. 864 - 867
  • Route3

    References

    • Zhang, Yun; Jamison, Timothy F.; Patel, Sejal; Mainolfi, Nello Organic Letters, 2011 , vol. 13, # 2 p. 280 - 283

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.2434
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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