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CS-W001157 4
Total: USD 88.00

2,5-Difluoroterephthalaldehyde

  • CAS No. 608145-27-3

  • Cat. No. CS-0161515
  • Purity≥97%
  • MDL No.MFCD31432044

*For research and further manufacturing use only, not for direct human use.

2,5-Difluoroterephthalaldehyde|CS-0161515

Structure of 608145-27-3

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General Information

  • CAS No. 608145-27-3
  • Cat. No. CS-0161515
  • Purity ≥97%
  • MDL No. MFCD31432044
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄F₂O₂
  • Molecular Weight 170.11
  • Synonym(s) None
  • SMILES O=CC1=CC(F)=C(C=O)C=C1F

Description

2,5-Difluoroterephthalaldehyde features a rigid aromatic core with two fluorine substituents positioned para to the aldehyde groups, enhancing electron-withdrawal and metabolic stability. This configuration supports efficient coupling in transition-metal-catalyzed cross-couplings and enables selective functionalization in pharmaceutical and materials synthesis.

Application

2,5-Difluoroterephthalaldehyde serves as a valuable building block in the synthesis of fluorinated aromatic scaffolds, enabling efficient access to biologically relevant heterocycles and pharmaceutical intermediates. Its dual aldehyde functionalities exhibit high reactivity in condensation reactions, while the ortho-fluoro substituents provide enhanced metabolic stability and modulate electronic properties. The compound demonstrates excellent bench stability and compatibility with standard purification techniques, facilitating seamless integration into multi-step synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   34.14
  • LogP   1.5898
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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