(S)-3-Chloropropane-1,2-diol

Name: (S)-3-Chloropropane-1,2-diol
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CAS No. 60827-45-4
Cat. No. CS-W011275
Molecule weight110.54
Purity≥97%
MDL No.MFCD00210270

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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Structure of 60827-45-4

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General Information

CAS No. 60827-45-4
Cat. No. CS-W011275
Purity ≥97%
MDL No. MFCD00210270
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃H₇ClO₂
Molecular Weight 110.54
Synonym(s) S-3-chloro-1,2-propanediol
SMILES OC[C@H](O)CCl

Description

(S)-3-Chloropropane-1,2-diol is a chiral epoxide precursor featuring a stereodefined hydroxyl-bearing carbon framework. This bench-stable diol integrates readily into asymmetric synthesis workflows, where its regioselective functionalization enables efficient access to enantiopure intermediates for pharmaceutical and agrochemical applications.

Application

(S)-3-Chloropropane-1,2-diol serves as a chiral building block for synthesizing epoxides, β-amino alcohols, and heterocyclic scaffolds relevant to medicinal chemistry. Its stereochemical integrity enables stereoselective transformations in API synthesis, while its hydroxyl and chloro functionalities offer orthogonal reactivity for sequential functionalization. Bench-stable and amenable to standard purification methods, it facilitates reliable access to complex molecular architectures.

Synthesis

Route1
- 106-89-8
- ~46%
- 51594-55-9
- In-stock
  
  60827-45-4
References
- Tetrahedron Letters, , vol. 48, # 22 p. 3793 - 3796
Route2
- 24423-98-1
- ~%
- In-stock
  
  60827-45-4
References
- EP1422213 A1, ; Page 18 ;
Route3
- 106-89-8
- ~0%
- 51594-55-9
- In-stock
  
  57090-45-6
- In-stock
  
  60827-45-4
References
- Schaus, Scott E.; Brandes, Bridget D.; Larrow, Jay F.; Tokunaga, Makoto; Hansen, Karl B.; Gould, Alexandra E.; Furrow, Michael E.; Jacobsen, Eric N. Journal of the American Chemical Society, 2002 , vol. 124, # 7 p. 1307 - 1315

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS06
Signal Word : Danger	UN#: 2689
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301-H312-H318
Precautionary Statements : P264-P270-P280-P302+P352-P330-P363-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 40.46
LogP -0.4216
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Fatty chain compounds

Key Words

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(S)-3-Chloropropane-1,2-diol

CAS No. 60827-45-4

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