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CS-W001157 4
Total: USD 88.00

O-Phenylhydroxylamine hydrochloride

  • CAS No. 6092-80-4

  • Cat. No. CS-0022011
  • Purity≥98%
  • MDL No.MFCD00043271

*For research and further manufacturing use only, not for direct human use.

O-Phenylhydroxylamine hydrochloride|CS-0022011

Structure of 6092-80-4

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General Information

  • CAS No. 6092-80-4
  • Cat. No. CS-0022011
  • Purity ≥98%
  • MDL No. MFCD00043271
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈ClNO
  • Molecular Weight 145.59
  • Synonym(s) PHENOXYAMINE HYDROCHLORIDE
  • SMILES NOC1=CC=CC=C1.[H]Cl

Description

O-Phenylhydroxylamine hydrochloride offers a stable, bench-ready source of nucleophilic hydroxylamine functionality. This moisture-tolerant reagent integrates readily into condensation and coupling reactions, enabling efficient access to oxime derivatives under mild conditions.

Application

O-Phenylhydroxylamine hydrochloride serves as a reliable precursor for the synthesis of azo dyes, heterocycles, and pharmaceutical intermediates. Its bench-stable form facilitates safe handling and consistent reactivity in electrophilic substitution and coupling reactions. The compound functions effectively in nitrosation and condensation processes, offering good functional group tolerance and straightforward purification.

Synthesis

  • Route1
    • null|null
      4846-21-3
    • ~77%
    • In-stock
      O-Phenylhydroxylamine hydrochloride|CS-0022011
      6092-80-4

    References

    • The Scripps Research Institute Patent: US2006/178527 A1, 2006 ; Location in patent: Page/Page column 8; sheet 6 ;
  • Route2
    • tert-Butyl phenoxycarbamate|CS-1683076
      76570-49-5
    • ~82%
    • In-stock
      O-Phenylhydroxylamine hydrochloride|CS-0022011
      6092-80-4

    References

    • Baldoli, Clara; Buttero, Paola Del; Licandro, Emanuela; Maiorana, Stefano Synthesis, 1988 , # 4 p. 344 - 345
  • Route3
    • null|null
      108-95-2
    • ~%
    • In-stock
      O-Phenylhydroxylamine hydrochloride|CS-0022011
      6092-80-4

    References

    • Journal of Organic Chemistry, , vol. 49, p. 1348 - 1352

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.3609
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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