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CS-W001157 4
Total: USD 88.00

4-Hydroxyphthalic acid

  • CAS No. 610-35-5

  • Cat. No. CS-D0572
  • Purity≥96%
  • MDL No.MFCD00013984

*For research and further manufacturing use only, not for direct human use.

4-Hydroxyphthalic acid|CS-D0572

Structure of 610-35-5

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General Information

  • CAS No. 610-35-5
  • Cat. No. CS-D0572
  • Purity ≥96%
  • MDL No. MFCD00013984
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆O₅
  • Molecular Weight 182.13
  • Synonym(s) 4-Hydroxybenzene-1,2-dicarboxylic acid
  • SMILES O=C(O)C1=CC=C(O)C=C1C(=O)O

Description

4-Hydroxyphthalic acid is a bifunctional aromatic diacid featuring a hydroxyl group at the para position relative to one carboxylic acid. This strategic substitution enhances solubility and enables direct incorporation into polyesters, copolymers, and chelating architectures. The molecule's stability under standard conditions supports reliable use in synthetic and materials applications.

Application

4-Hydroxyphthalic acid serves as a versatile building block in synthetic organic chemistry, enabling the construction of functionalized heterocycles and pharmaceutical intermediates. Its ortho-dicarboxylic acid framework with a phenolic hydroxyl group provides excellent reactivity in condensation reactions, esterifications, and metal complexation. The compound exhibits good bench stability and facilitates straightforward purification via recrystallization, making it well-suited for iterative synthesis workflows in medicinal chemistry and materials science.

Synthesis

  • Route1
    • 4-Sulfophthalic acid|CS-0204821
      89-08-7
    • ~71%
    • In-stock
      4-Hydroxyphthalic acid|CS-D0572
      610-35-5

    References

    • US2013/90404 A1, ; Paragraph 0071; 0072; 0073; 0074 ;
  • Route2

    References

    • US6689922 B1, ; Page column 20 ;
  • Route3

    References

    • Chemische Berichte, , vol. 12, p. 818,821

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   94.83
  • LogP   0.7886
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   2

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