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2'-Hydroxypropiophenone

  • CAS No. 610-99-1

  • Cat. No. CS-0064037
  • Purity≥95%
  • MDL No.MFCD00002220

*For research and further manufacturing use only, not for direct human use.

2'-Hydroxypropiophenone|CS-0064037

Structure of 610-99-1

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General Information

  • CAS No. 610-99-1
  • Cat. No. CS-0064037
  • Purity ≥95%
  • MDL No. MFCD00002220
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀O₂
  • Molecular Weight 150.18
  • Synonym(s) None
  • SMILES O=C(C=1C=CC=CC1O)CC

Description

2'-Hydroxypropiophenone features a hydroxyl group ortho to the ketone, enhancing its reactivity in photocatalytic systems. This bench-stable compound integrates readily into synthetic sequences requiring electron-deficient aryl moieties. The adjacent hydroxyl facilitates intramolecular hydrogen bonding, stabilizing transition states during radical generation.

Application

2'-Hydroxypropiophenone serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted benzophenones and heterocyclic scaffolds. Its ortho-hydroxyl group facilitates intramolecular cyclization and metal coordination, while the ketone functionality supports nucleophilic additions and condensation reactions. Bench-stable and readily purified by recrystallization, it functions effectively in standard reaction workflows requiring functional group tolerance and predictable reactivity.

Synthesis

  • Route1

    References

    • Synthetic Communications, , vol. 29, # 7 p. 1195 - 1200
  • Route2
    • null|null
      93-55-0
    • ~55%
    • In-stock
      2'-Hydroxypropiophenone|CS-0064037
      610-99-1

    References

    • Shan, Gang; Han, Xuesong; Lin, Yun; Yu, Shanyou; Rao, Yu Organic and Biomolecular Chemistry, 2013 , vol. 11, # 14 p. 2318 - 2322
  • Route3

    References

    • Ajjou, Abdelaziz Nait; Pinet, Jean-Louis Canadian Journal of Chemistry, 2005 , vol. 83, # 6-7 p. 702 - 710

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.9849
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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