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CS-W001157 4
Total: USD 88.00

4-Chloro-2-fluorobenzaldehyde

  • CAS No. 61072-56-8

  • Cat. No. CS-W007528
  • Purity≥98%
  • MDL No.MFCD00143282

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2-fluorobenzaldehyde|CS-W007528

Structure of 61072-56-8

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General Information

  • CAS No. 61072-56-8
  • Cat. No. CS-W007528
  • Purity ≥98%
  • MDL No. MFCD00143282
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄ClFO
  • Molecular Weight 158.56
  • Synonym(s) 4-Chlor-2-fluorbenzolcarbaldehyd
  • SMILES O=CC1=CC=C(Cl)C=C1F

Description

4-Chloro-2-fluorobenzaldehyde features a strategically positioned aldehyde group flanked by chlorine and fluorine substituents, enabling selective coupling in cross-coupling reactions. The electron-withdrawing halogens enhance electrophilicity at the carbonyl carbon while maintaining stability under standard conditions. This ortho-halogenated scaffold facilitates direct integration into pharmaceutical intermediates and functionalized aromatic systems.

Application

4-Chloro-2-fluorobenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of substituted heterocycles and biaryl scaffolds. Its ortho-fluoro and para-chloro substituents provide enhanced reactivity in palladium-catalyzed cross-coupling reactions while maintaining bench stability and compatibility with common protecting group strategies.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS09
Signal Word : Warning
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H315-H319-H411
Precautionary Statements : P264-P273-P280-P302+P352-P362-P391-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.2916
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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