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CS-W001157 4
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5-Bromo-1,2,3,4-tetrahydronaphthalene

  • CAS No. 6134-55-0

  • Cat. No. CS-0159081
  • Purity≥97%
  • MDL No.MFCD08361743

*For research and further manufacturing use only, not for direct human use.

5-Bromo-1,2,3,4-tetrahydronaphthalene|CS-0159081

Structure of 6134-55-0

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General Information

  • CAS No. 6134-55-0
  • Cat. No. CS-0159081
  • Purity ≥97%
  • MDL No. MFCD08361743
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁Br
  • Molecular Weight None
  • Synonym(s) 5-Bromo-1,2,3,4-tetrahydro-phthalene
  • SMILES BrC1=CC=CC2=C1CCCC2

Description

5-Bromo-1,2,3,4-tetrahydronaphthalene features a bromine substituent at the 5-position of a saturated naphthalene core, providing a reactive handle for cross-coupling and functionalization. This bench-stable, moisture-tolerant intermediate integrates readily into synthetic sequences requiring electron-deficient aromatic systems or steric control in complex molecule assembly.

Application

5-Bromo-1,2,3,4-tetrahydronaphthalene serves as a versatile building block in medicinal chemistry and materials synthesis, enabling efficient functionalization via palladium-catalyzed cross-coupling reactions. The bromine substituent provides high reactivity in Suzuki, Stille, and Negishi couplings, while the tetrahydronaphthalene core offers structural rigidity and lipophilicity beneficial for drug-like molecule design. Bench-stable and readily purified by distillation or chromatography, it functions reliably in multi-step syntheses requiring orthogonal reactivity and predictable transformation pathways.

Safety Information

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GHS Pictogram :
GHS No : GHS07,GHS09
Signal Word : Warning
UN#: 3082
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H319-H410
Precautionary Statements : P264-P270-P273-P280-P330-P391-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   3.3279
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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