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CS-W001157 4
Total: USD 88.00

Ethyl 2,2-dichloro-3-oxobutanoate

  • CAS No. 6134-66-3

  • Cat. No. CS-W010521
  • Purity≥97%
  • MDL No.MFCD00129136
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Ethyl 2,2-dichloro-3-oxobutanoate|CS-W010521

Structure of 6134-66-3

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Description

Ethyl 2,2-dichloro-3-oxobutanoate features a sterically hindered α,α-dichloro ketone moiety that enables direct functionalization at the carbonyl center. This bench-stable reagent integrates readily into synthetic sequences requiring electrophilic halogenation or tandem Claisen-type condensations. The dichloro substitution enhances reactivity in nucleophilic addition pathways while maintaining handling ease under standard conditions.

Application

Ethyl 2,2-dichloro-3-oxobutanoate serves as a versatile building block in synthetic organic chemistry, enabling the construction of chlorinated heterocycles and functionalized carbonyl intermediates. Its α,α-dichloro ketone functionality facilitates nucleophilic addition and enolization under mild conditions, while the ester group supports subsequent transformations. The compound exhibits good bench stability and is compatible with standard purification methods, making it valuable for iterative synthesis workflows in medicinal chemistry and process development.

General Information

  • CAS No. 6134-66-3
  • Cat. No. CS-W010521
  • Purity ≥97%
  • MDL No. MFCD00129136
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈Cl₂O₃
  • Molecular Weight 199.03
  • Synonym(s) ethyl 2,2-dichloroacetoacetate
  • SMILES CC(C(Cl)(Cl)C(OCC)=O)=O

Computational Chemistry Data

  • TPSA   43.37
  • LogP   1.3124
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2920
Class : 8 (3)
Packing Group :
Hazard Statements : H226-H302-H314-H318-H335-H412
Precautionary Statements : P210-P273-P280

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