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Structure of 61514-54-3
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4-Ethynyl-1,5-dimethyl-1H-pyrazole features a reactive terminal alkyne paired with a sterically protected pyrazole core. This combination enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) under mild conditions. The molecule's bench-stable nature and compatibility with aqueous environments streamline integration into bioconjugation workflows and small-molecule library construction.
4-Ethynyl-1,5-dimethyl-1H-pyrazole serves as a versatile building block in transition-metal-catalyzed coupling reactions, particularly enabling efficient Sonogashira and CuAAC transformations. The terminal alkyne functionality exhibits excellent stability under standard bench conditions and tolerates a range of functional groups, facilitating rapid access to substituted pyrazole scaffolds. Its defined regiochemistry and predictable reactivity make it ideal for constructing complex heterocyclic architectures in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 3259
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H227-H315-H318-H335
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Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P403-P405-P501
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Lot numbers can be found on the outside label of a product: