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Structure of 61727-33-1
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This pyrimidine carboxylic acid features a chloro group at C5 and a methylthio substituent at C2, creating a highly functionalized scaffold. The electron-withdrawing chlorine and sulfur-containing side chain enhance reactivity in coupling processes. This compound serves as a key intermediate for bioactive heterocycles, particularly in medicinal chemistry applications requiring tailored electronic and steric profiles.
5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of pyrimidine-based heterocycles through nucleophilic substitution and coupling reactions. The chloro group at C5 facilitates regioselective functionalization, while the methylthio and carboxylic acid moieties offer orthogonal reactivity for further derivatization. Its bench-stable nature and compatibility with standard synthetic protocols make it well-suited for API intermediate development and high-throughput screening campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501
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Lot numbers can be found on the outside label of a product: