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CS-W001157 4
Total: USD 88.00

4-Chlorobenzamide

  • CAS No. 619-56-7

  • Cat. No. CS-W019519
  • Molecule weight155.58
  • Purity≥96%
  • MDL No.MFCD00007993

*For research and further manufacturing use only, not for direct human use.

4-Chlorobenzamide|CS-W019519

Structure of 619-56-7

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General Information

  • CAS No. 619-56-7
  • Cat. No. CS-W019519
  • Purity ≥96%
  • MDL No. MFCD00007993
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClNO
  • Molecular Weight 155.58
  • Synonym(s) None
  • SMILES O=C(N)C1=CC=C(Cl)C=C1

Description

4-Chlorobenzamide features a para-chloro substituent on a benzamide core, delivering enhanced electronic and steric properties. This stable, bench-ready compound integrates readily into synthetic routes requiring electron-deficient aromatic amides. It serves as a key intermediate in pharmaceutical and agrochemical development.

Application

4-Chlorobenzamide serves as a versatile building block in medicinal chemistry and materials science, enabling efficient construction of aromatic amides through standard coupling reactions. Its chlorine substituent provides a handle for further functionalization via palladium-catalyzed cross-coupling, while the amide group offers enhanced solubility and metabolic stability. Bench-stable and readily purified by recrystallization, it functions reliably in multistep syntheses requiring robust functional group tolerance.

Synthesis

  • Route1

    References

    • Martinez-Asencio, Ana; Yus, Miguel; Ramon, Diego J. Tetrahedron, 2012 , vol. 68, # 21 p. 3948 - 3951
  • Route2
    • In-stock
      1-Chloro-4-iodobenzene|CS-W007395
      637-87-6
    • null|null
      201230-82-2
    • ~94%
    • In-stock
      4-Chlorobenzamide|CS-W019519
      619-56-7

    References

    • Xu, Tongyu; Alper, Howard Tetrahedron Letters, 2013 , vol. 54, # 40 p. 5496 - 5499
  • Route3

    References

    • Kim, Min; Lee, Jinwoo; Lee, Hee-Yoon; Chang, Sukbok Advanced Synthesis and Catalysis, 2009 , vol. 351, # 11-12 p. 1807 - 1812

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.09
  • LogP   1.4389
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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