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Structure of 6198-58-9
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2-Bromobenzaldehyde is a versatile building block used in Suzuki-Miyaura and Buchwald-Hartwig reactions, cross-coupling reactions to form carbon-carbon or carbon-heteroatom bondsSynthetic applications of 2-bromobenzaldehyde include:Synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction.Preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.It is a key starting material in the total synthesis of an anticancer agent, (-)-taxol.Palladium/copper-catalyzed coupling and cyclization of terminal acetylenes derived from 2-bromobenzaldehyde and unsaturated imines can be used in the synthesis of wide range of isoquinolines, including decumbenine B.Fluoren-9-ones can be synthesized by annulation of arynes, generated in situ from 2-(trimethylsilyl)aryl triflates, with 2-bromobenzaldehyde in the presence of palladium(0) catalyst.It can also be used to build a variety of steroid frameworks, in which ring A is derived from 2-bromobenzaldehyde.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: