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CS-W001157 4
Total: USD 88.00

2-(Benzofuran-2-yl)acetic acid

  • CAS No. 62119-70-4

  • Cat. No. CS-0138270
  • Purity≥97%
  • MDL No.MFCD00052742

*For research and further manufacturing use only, not for direct human use.

2-(Benzofuran-2-yl)acetic acid|CS-0138270

Structure of 62119-70-4

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General Information

  • CAS No. 62119-70-4
  • Cat. No. CS-0138270
  • Purity ≥97%
  • MDL No. MFCD00052742
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₈O₃
  • Molecular Weight 176.17
  • Synonym(s) 2-BENZOFURANACETIC ACID
  • SMILES O=C(O)CC1=CC2=CC=CC=C2O1

Description

2-(Benzofuran-2-yl)acetic acid features a benzofuran scaffold linked to a carboxylic acid-bearing side chain, enabling direct integration into bioactive molecule scaffolds. This structural motif enhances π-stacking potential and modulates solubility, supporting its use in medicinal chemistry and polymer functionalization under standard conditions.

Application

2-(Benzofuran-2-yl)acetic acid serves as a versatile building block for synthesizing bioactive heterocycles and pharmaceutical intermediates. Its carboxylic acid functionality enables direct derivatization via esterification, amidation, or coupling reactions, while the benzofuran core provides structural rigidity and π-conjugation beneficial for drug-like properties. The compound exhibits good bench stability and is compatible with standard synthetic workflows, facilitating efficient access to diverse analogs in medicinal chemistry campaigns.

Synthesis

  • Route1
    • 2-(1-Benzofuran-2-yl)acetonitrile|CS-0229861
      95-28-3
    • ~%
    • In-stock
      2-(Benzofuran-2-yl)acetic acid|CS-0138270
      62119-70-4

    References

    • Journal of the American Chemical Society, , vol. 73, p. 4400,4403
  • Route2
    • null|null
      335060-44-1
    • ~%
    • In-stock
      2-(Benzofuran-2-yl)acetic acid|CS-0138270
      62119-70-4

    References

    • US6660727 B1, ; Page column 11 ;
  • Route3
    • Methyl 2-(benzofuran-2-yl)acetate|CS-0452098
      39581-61-8
    • ~%
    • In-stock
      2-(Benzofuran-2-yl)acetic acid|CS-0138270
      62119-70-4

    References

    • US6057357 A1, ; US 6057357 A

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.44
  • LogP   2.0599
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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