(R)-1,2-Dimethylpiperazine

Name: (R)-1,2-Dimethylpiperazine
Brand: ChemScene
Availability: InStock
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CAS No. 623586-02-7
Cat. No. CS-0006864
Purity≥98%
MDL No.MFCD11858460

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 623586-02-7

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Description

(R)-1,2-Dimethylpiperazine is a chiral piperazine derivative featuring two methyl groups at the 1- and 2-positions, conferring enhanced steric bulk and defined stereochemistry. This configuration imparts favorable solubility and stability under standard bench conditions, enabling reliable integration into medicinal chemistry campaigns. The molecule serves as a modular scaffold for constructing bioactive compounds, particularly in kinase inhibitor and CNS-targeted drug discovery programs where stereocontrol is critical.

Application

(R)-1,2-Dimethylpiperazine serves as a versatile chiral building block in medicinal chemistry, enabling the construction of bioactive heterocycles with defined stereochemistry. Its tertiary amine functionality offers favorable solubility and basicity, while the rigid piperazine core enhances target binding affinity. The compound exhibits bench stability and facilitates efficient derivatization via alkylation or acylation, making it well-suited for parallel synthesis campaigns and API development workflows.

General Information

CAS No. 623586-02-7
Cat. No. CS-0006864
Purity ≥98%
MDL No. MFCD11858460
Storage 4°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₄N₂
Molecular Weight 114.19
Synonym(s) (R)-1,2-Dimethyl-piperazine dihydrochloride
SMILES C[C@H]1N(C)CCNC1

Computational Chemistry Data

TPSA 15.27
LogP -0.0901
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS02,GHS05
Signal Word : Danger	UN#: 2924
Class : 3,8	Packing Group : Ⅲ
Hazard Statements : H226-H314
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-1,2-Dimethylpiperazine

CAS No. 623586-02-7

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