1-(4-Bromo-2-fluorophenyl)ethanone

Name: 1-(4-Bromo-2-fluorophenyl)ethanone
Brand: ChemScene
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CAS No. 625446-22-2
Cat. No. CS-W004323
Purity≥98%
MDL No.MFCD03411551

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-(4-Bromo-2-fluorophenyl)ethanone|CS-W004323

Structure of 625446-22-2

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Description

1-(4-Bromo-2-fluorophenyl)ethanone features a brominated and fluorinated aromatic core paired with a reactive ketone group, enabling direct incorporation into Suzuki-Miyaura cross-coupling and electrophilic substitution workflows. This bench-stable building block delivers high functional group tolerance and compatibility with transition-metal catalysis under standard conditions.

Application

1-(4-Bromo-2-fluorophenyl)ethanone serves as a versatile building block in medicinal chemistry, enabling efficient construction of biaryl and heterocyclic scaffolds. Its bromo and fluoro substituents provide orthogonal functional handles for palladium-catalyzed cross-coupling reactions and directed ortho-metalation. The ketone group facilitates nucleophilic additions and acts as a key synthetic intermediate in the development of API candidates. Bench-stable and readily purified by crystallization, it supports scalable synthesis and integration into multi-step workflows.

General Information

CAS No. 625446-22-2
Cat. No. CS-W004323
Purity ≥98%
MDL No. MFCD03411551
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₆BrFO
Molecular Weight 217.04
Synonym(s) 1-(4-Bromo-2-fluorophenyl)ethan-1-one
SMILES Brc1ccc(c(c1)F)C(=O)C

Computational Chemistry Data

TPSA 17.07
LogP 2.7908
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Ketone

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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1-(4-Bromo-2-fluorophenyl)ethanone

CAS No. 625446-22-2

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