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Structure of 625470-33-9
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Methyl 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate delivers a boronate ester group flanked by a chlorinated aromatic ring and an ester functionality. This bench-stable reagent integrates seamlessly into Suzuki-Miyaura coupling reactions, enabling efficient C–C bond formation under standard conditions. The tetramethylcyclopentadienylboron moiety enhances stability and reactivity, while the ortho-chloro substituent offers downstream functionalization potential.
Methyl 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. The pendant chloro group enables sequential functionalization via palladium-catalyzed coupling or nucleophilic substitution, while the pinacol boronate moiety offers excellent stability, ease of handling, and compatibility with diverse reaction conditions. Its orthogonal reactivity profile facilitates efficient construction of biaryl and heteroaryl scaffolds in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: