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Structure of 625471-27-4
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Methyl 2-fluoro-5-iodobenzoate features a strategically positioned fluorine and iodine substituent on the aromatic ring, enabling selective cross-coupling reactions. The electron-withdrawing fluorine enhances reactivity in palladium-catalyzed transformations, while the iodide serves as a high-efficiency coupling handle. This ortho-fluoro-para-iodo motif delivers predictable regiochemistry in biaryl synthesis under standard conditions.
Methyl 2-fluoro-5-iodobenzoate serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient access to substituted aryl scaffolds. The ortho-fluoro and meta-iodo groups provide complementary reactivity for sequential functionalization, while the methyl ester offers a stable, bench-compatible handle. Its compatibility with palladium-catalyzed couplings and tolerance to common reaction conditions make it well-suited for medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: