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Structure of 6271-78-9
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6-Chloronicotinamide features a chlorinated pyridine core with a stable amide functional group, enabling direct incorporation into bioactive scaffolds. This bench-stable compound serves as a key building block in medicinal chemistry, particularly for targeting kinase pathways and optimizing pharmacokinetic profiles through halogen bonding interactions.
6-Chloronicotinamide serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through palladium-catalyzed cross-coupling reactions. Its chlorine substituent provides high reactivity in Suzuki, Stille, and Buchwald–Hartwig transformations, while the amide functionality offers enhanced solubility and metabolic stability. The compound exhibits excellent bench stability and is readily purified by recrystallization, facilitating integration into multi-step synthetic sequences for API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: