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Structure of 627526-90-3
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1-Bromo-3-(difluoromethyl)-5-fluorobenzene features a strategically positioned difluoromethyl group that enhances metabolic stability and modulates electronic properties. The para-fluoro substitution imparts electron-withdrawing character, while the bromo handle enables efficient cross-coupling reactions. This compound serves as a valuable building block for fluorinated aromatic scaffolds in medicinal chemistry and agrochemical development.
1-Bromo-3-(difluoromethyl)-5-fluorobenzene serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions to construct biaryl architectures. The difluoromethyl group imparts enhanced metabolic stability and modulates electronic properties, while the bromo and fluoro substituents offer orthogonal reactivity for sequential functionalization. Bench-stable and compatible with standard coupling conditions, it facilitates efficient access to fluorinated aromatic scaffolds relevant to API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: