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CS-W001157 4
Total: USD 88.00

1,4-Diiodobutane

  • CAS No. 628-21-7

  • Cat. No. CS-W004871
  • Molecule weight309.92
  • Purity≥98%
  • MDL No.MFCD00001099

*For research and further manufacturing use only, not for direct human use.

1,4-Diiodobutane|CS-W004871

Structure of 628-21-7

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General Information

  • CAS No. 628-21-7
  • Cat. No. CS-W004871
  • Purity ≥98%
  • MDL No. MFCD00001099
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈I₂
  • Molecular Weight 309.92
  • Synonym(s) None
  • SMILES ICCCCI

Description

1,4-Diiodobutane serves as a versatile dihalide linker for constructing cyclic and acyclic frameworks in synthetic organic chemistry. This linear alkyl diiodide features reactive C–I bonds that facilitate efficient coupling reactions, including cross-coupling and cyclization processes. The molecule exhibits high stability under standard conditions and enables precise spatial control in molecular design.

Application

1,4-Diiodobutane serves as a versatile dihalide building block for the synthesis of cyclic and acyclic compounds via double alkylation or transition-metal-catalyzed coupling reactions. Its well-defined reactivity enables efficient construction of 1,4-difunctionalized scaffolds, including heterocycles and macrocyclic frameworks. The compound exhibits good bench stability and facilitates clean functional group transformations with minimal side-product formation, making it suitable for scalable synthetic applications in medicinal chemistry and materials science.

Synthesis

  • Route1
    • null|null
      110-52-1
    • ~89%
    • In-stock
      1,4-Diiodobutane|CS-W004871
      628-21-7

    References

    • Chiles, Margaret Shea; Jackson, Donald D.; Reeves, Perry C. Journal of Organic Chemistry, 1980 , vol. 45, # 14 p. 2915 - 2918
  • Route2
    • null|null
      110-56-5
    • ~0%
    • In-stock
      1,4-Diiodobutane|CS-W004871
      628-21-7
    • In-stock
      1-Chloro-4-iodobutane|CS-W019348
      10297-05-9

    References

    • Hahn, Roger C. Journal of Organic Chemistry, 1988 , vol. 53, # 6 p. 1331 - 1333
  • Route3
    • null|null
      109-99-9
    • ~88%
    • In-stock
      1,4-Diiodobutane|CS-W004871
      628-21-7

    References

    • Makovetskii, Yu. P.; Feshchenko, N. G. J. Gen. Chem. USSR (Engl. Transl.), 1985 , vol. 55, # 5 p. 1003 - 1006,894 - 896

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.6366
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   3

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