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Structure of 6294-93-5
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4-Chloro-3-(trifluoromethyl)phenol features a trifluoromethyl group flanking a chlorinated aromatic ring, delivering enhanced electron-withdrawal and metabolic stability. This configuration supports direct functionalization in cross-coupling reactions and facilitates integration into bioactive scaffolds requiring halogen-directed reactivity. The compound exhibits robust bench stability and compatibility with diverse reaction conditions.
4-Chloro-3-(trifluoromethyl)phenol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the phenolic hydroxyl group and ortho-chlorine site. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the chlorine facilitates palladium-catalyzed cross-coupling reactions. The compound exhibits good bench stability and compatibility with standard purification methods, making it ideal for constructing complex heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H319
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: