4,6-Dichloropyrimidin-2(1H)-one

Name: 4,6-Dichloropyrimidin-2(1H)-one
Brand: ChemScene
Availability: InStock
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CAS No. 6297-80-9
Cat. No. CS-W006788
Purity≥97%
MDL No.MFCD09033880

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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4,6-Dichloropyrimidin-2(1H)-one|CS-W006788

Structure of 6297-80-9

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Description

4,6-Dichloropyrimidin-2(1H)-one serves as a pivotal electrophilic scaffold in heterocyclic synthesis, featuring two chlorine atoms at electron-deficient positions that enable efficient functionalization. This bench-stable compound integrates readily into nucleophilic substitution cascades, delivering diverse pyrimidine derivatives with high regiocontrol under mild conditions.

Application

4,6-Dichloropyrimidin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through nucleophilic substitution. The dichloro substituents at C4 and C6 provide orthogonal reactivity for sequential functionalization, while the pyrimidinone core offers excellent bench stability and compatibility with common reaction conditions. Its well-defined regioselectivity facilitates the synthesis of targeted analogs in drug discovery campaigns.

General Information

CAS No. 6297-80-9
Cat. No. CS-W006788
Purity ≥97%
MDL No. MFCD09033880
Storage -20°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₂Cl₂N₂O
Molecular Weight 164.98
Synonym(s) 4,6-dichloro-1H-pyrimidin-2-one
SMILES O=C1N=C(Cl)C=C(Cl)N1

Computational Chemistry Data

TPSA 45.75
LogP 1.0767
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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4,6-Dichloropyrimidin-2(1H)-one

CAS No. 6297-80-9

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