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Structure of 630125-49-4
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1-Bromo-3-nitro-5-(trifluoromethyl)benzene features a trifluoromethyl group flanked by electron-withdrawing nitro and bromo substituents, creating a highly electron-deficient aromatic core. This structural motif enables selective cross-coupling reactions under palladium catalysis, particularly in the synthesis of fluorinated biaryl scaffolds for pharmaceutical and agrochemical applications. The compound exhibits bench-stable handling characteristics and tolerates standard reaction conditions.
1-Bromo-3-nitro-5-(trifluoromethyl)benzene serves as a versatile building block in medicinal chemistry and materials science, enabling palladium-catalyzed cross-coupling reactions due to its ortho-brominated aryl functionality. The nitro and trifluoromethyl groups provide strong electron-withdrawing effects, enhancing reactivity in nucleophilic aromatic substitution and facilitating further functionalization. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for modular synthesis of complex heterocycles and bioactive scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: