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CS-W001157 4
Total: USD 88.00

1-(Azetidin-1-yl)-2-chloroethan-1-one

  • CAS No. 63177-41-3

  • Cat. No. CS-0054578
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(Azetidin-1-yl)-2-chloroethan-1-one|CS-0054578

Structure of 63177-41-3

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General Information

  • CAS No. 63177-41-3
  • Cat. No. CS-0054578
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₈ClNO
  • Molecular Weight 133.58
  • Synonym(s) 1-Azetidin-1-yl-2-chloro-ethanone
  • SMILES ClCC(N1CCC1)=O

Description

1-(Azetidin-1-yl)-2-chloroethan-1-one features a reactive acyl chloride moiety paired with a strained azetidine ring, enabling efficient conjugation in synthetic transformations. This electrophilic scaffold integrates readily into peptide and heterocyclic architectures under mild conditions. The compound exhibits enhanced stability compared to analogous reagents, facilitating handling in standard bench protocols.

Application

1-(Azetidin-1-yl)-2-chloroethan-1-one serves as a versatile acylating agent in synthetic organic chemistry, enabling efficient introduction of the azetidinyl carbonyl moiety into target molecules. Its reactivity facilitates nucleophilic acyl substitution under mild conditions, with good bench stability and compatibility across diverse functional groups. This compound functions as a key building block for constructing nitrogen-containing heterocycles and bioactive scaffolds, particularly in medicinal chemistry campaigns requiring constrained amide linkages.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

  • TPSA   20.31
  • LogP   0.4575
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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