Lot numbers can be found on the outside label of a product:
2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine
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CAS No. 63200-54-4
- Cat. No. CS-W003450
- Purity≥98%
- MDL No.MFCD08059281
*For research and further manufacturing use only, not for direct human use.
![2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine|CS-W003450](https://file.chemscene.com/productPIC/CS-W003450.gif)
Structure of 63200-54-4
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General Information
- CAS No. 63200-54-4
- Cat. No. CS-W003450
- Purity ≥98%
- MDL No. MFCD08059281
- Storage -20°C, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₃Cl₂N₃
- Molecular Weight 188.01
- Synonym(s) 5H-Pyrrolo[3,2-d]pyrimidine, 2,4-dichloro-
- SMILES Clc1nc(Cl)c2c(n1)cc[nH]2
Description
2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine is a heterocyclic scaffold featuring two chlorine substituents at electron-deficient positions, enabling direct functionalization in cross-coupling reactions. This bench-stable, moisture-tolerant core integrates readily into bioactive molecules and advanced materials, offering high reactivity under mild conditions.
Application
2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of purine-based heterocycles. Its dichloro substitution pattern facilitates selective cross-coupling reactions and nucleophilic aromatic substitution, offering high functional group tolerance and bench stability. The compound functions as a key intermediate in the synthesis of kinase inhibitors and other bioactive scaffolds, with predictable reactivity under standard conditions.
Synthesis
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Route1
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In-stock
![1,5-Dihydro-2H-pyrrolo[3,2-d]pyrimidine-2,4(3H)-dione|CS-W003447](https://file.chemscene.com/productPIC/CS-W003447.gif)
65996-50-1 - ~76%
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In-stock
63200-54-4
References
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Girgis, Nabih S.; Cottam, Howard B.; Larson, Steven B.; Robins, Roland K. Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 821 - 827
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Route2
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![5-Benzyl-2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine|CS-0732950](https://file.chemscene.com/productPIC/CS-0732950.gif)
129872-83-9 - ~80%
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In-stock
63200-54-4
References
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VALEANT RESEARCH and DEVELOPMENT Patent: WO2006/122003 A2, 2006 ; Location in patent: Page/Page column 33; 43-44 ; WO 2006/122003 A2
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Route3
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In-stock
16632-21-6 - ~%
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In-stock
63200-54-4
References
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Pharmaceutical Chemistry Journal, , vol. 22, # 2 p. 135 - 141 Khimiko-Farmatsevticheskii Zhurnal, , vol. 22, # 2 p. 185 - 191
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 41.57
- LogP 2.2647
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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