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Structure of 63264-29-9
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N2-Isobutyryl-2'-O-methylguanosine features a sterically hindered isobutyryl group at the N2 position and a 2'-O-methyl modification on the ribose, enhancing stability and resistance to enzymatic degradation. This dual protection supports robust incorporation in RNA synthesis workflows.
N2-Isobutyryl-2'-O-methylguanosine serves as a protected guanosine building block for oligonucleotide synthesis, offering enhanced stability and orthogonal protection. The N2-isobutyryl group provides robust protection against undesired side reactions during phosphoramidite coupling, while the 2'-O-methyl modification confers nuclease resistance and improved binding affinity. This derivative facilitates efficient incorporation into RNA analogs and supports scalable synthesis workflows with straightforward deprotection under mild conditions.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P501
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Lot numbers can be found on the outside label of a product: