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CS-W001157 4
Total: USD 88.00

2-(4-Phenoxyphenyl)acetic acid

  • CAS No. 6328-74-1

  • Cat. No. CS-W010407
  • Purity≥97%
  • MDL No.MFCD00079779
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-(4-Phenoxyphenyl)acetic acid|CS-W010407

Structure of 6328-74-1

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Description

2-(4-Phenoxyphenyl)acetic acid features a conjugated aryl ether linkage flanked by a carboxylic acid group, enabling robust integration into bioactive scaffolds. The phenoxy bridge enhances lipophilicity and metabolic stability, while the terminal acetic acid offers direct derivatization potential for amides, esters, or salt formation under standard conditions. This structure supports applications in medicinal chemistry and materials science where controlled polarity and structural rigidity are required.

Application

2-(4-Phenoxyphenyl)acetic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive compounds through standard functional group transformations. Its rigid biphenyl-like architecture provides structural stability and enhances target binding affinity. The carboxylic acid functionality facilitates derivatization via esterification, amidation, or coupling reactions, while the phenoxy substituent offers favorable lipophilicity and metabolic resistance. Bench-stable and readily purified by recrystallization, it functions reliably in multistep syntheses and scale-up processes.

General Information

  • CAS No. 6328-74-1
  • Cat. No. CS-W010407
  • Purity ≥97%
  • MDL No. MFCD00079779
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₂O₃
  • Molecular Weight None
  • Synonym(s) benzeneacetic acid, 4-phenoxy-
  • SMILES O=C(O)CC1=CC=C(OC2=CC=CC=C2)C=C1

Computational Chemistry Data

  • TPSA   46.53
  • LogP   3.106
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   4

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group :
Hazard Statements : H302-H317-H318-H410
Precautionary Statements : P261-P264-P270-P272-P273-P280-P302+P352-P330-P362+P364-P391-P501

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